Nasopharyngeal carcinoma patients with retropharyngeal lymph. An imageable metastatic treatment model of nasopharyngeal. Carcinoma is cancer that starts in the cells that line the internal and external surfaces of the body called epithelial cells. Nasopharyngeal carcinoma npc is highly responsive to chemotherapy and effective palliation of symptoms, and prolongation of survival can often be achieved after chemotherapy for recurrent and metastatic disease with occasional observation of longterm survivors after treatment 1,2. Systemic therapies for recurrent or metastatic nasopharyngeal. Multicenter, phase ii study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma anthony t. When metastatic disease develops after curative radiotherapy, bone is the most frequently involved site, followed by the lungs and liver. An imageable metastatic treatment modelof nasopharyngeal.
They all start from epithelial sells that line the nasopharynx, but. Nasopharyngeal carcinoma npc is a tumor that is highly sensitive to both radiotherapy and chemotherapy. Nivolumab in treating patients with recurrent andor metastatic nasopharyngeal cancer rochester, mn this phase ii trial studies how well nivolumab works in treating patients with nasopharyngeal cancer that has returned after a period of improvement recurrent andor has spread to other parts of. Detection of bone metastasis in nasopharyngeal carcinoma.
Nasopharyngeal carcinoma metastatic to the cauda equina. This preliminary limited study sought to determine color duplex sonographic changes in successfully treated metastatic nodes from nasopharyngeal carcinoma. A phase ii study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma epsteinbarr virus dna as a biomarker of efficacy. The who classification for nasopharyngeal carcinoma has evolved over time and the 2005 classification is the current one. The patient, treated 3 years earlier for his primary disease, presented with bilateral weakness of his legs. A single arm monotherapy study of pazopanib in patients with who type iiiii nasopharyngeal carcinoma who had metastaticrecurrent disease and. Nasopharyngeal carcinoma npc is a tumour arising from the epithelial cells of nasopharynx. In march 20 he underwent a thyroid carcinoma radical operation, and histological examination revealed metastasis to the thyroid gland from nasopharyngeal carcinoma. A phase ii study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinumbased chemotherapy. Treatment for nasopharyngeal carcinoma usually involves radiation therapy, chemotherapy or a combination of the two. A case of nasopharyngeal carcinoma metastatic to the cauda equina is reported. Paclitaxel, carboplatin, and gemcitabine in metastatic. It is classified in two clinicohistologically distinct entities. For patients without distant metastatic lesions, radiotherapy is the standard treatment for nasopharyngeal carcinoma.
Nov 19, 20 to retrospectively analyze the prognosis of patients with nasopharyngeal carcinoma npc initially presenting with liver metastasis, in order to identify independent prognostic factors to facilitate management of treatment. Treatment for metastatic nasopharyngeal carcinoma sciencedirect. Full text management of recurrent nasopharyngeal carcinoma. Reliable modelling of progressionfree survival pfs and overall survival os. A retrospective study in perspective of limited resource settings 3 months after diagnosis. An imageable metastatic treatment modelof nasopharyngeal carcinoma tengfei liu, 1,2 yanqin ding, 1weibing xie, 1zuguo li,1xiaoyan bai, 1xin li,1weiyi fang,1caiping ren, 2 shuangwang,1robert m. Nasopharyngeal carcinoma the most frequent presenting complaint is a neck mass due to regional lymph node metastasis virology of epsteinbarr virus associated with the development of b cell lymphomas, t cell lymphomas, hodgkin lymphoma and nasopharyngeal carcinomas in certain patients. Nasopharyngeal cancer is a disease in which malignant cancer cells form in the tissues of the nasopharynx. Two nasopharyngeal carcinoma cell lines, stably expressing green fluorescent protein gfp, 58fgfp and 610bgfp, were established. We hypothesized that pazopanib would have antiangiogenic activity in nasopharyngeal carcinoma. Multiinstitutional prospective study of nedaplatin plus s. To the best of our knowledge, no cases have yet been reported regarding nasopharyngeal carcinoma metastasis to the mammary gland.
Capecitabine monotherapy had activity in recurrentmetastatic nasopharyngeal carcinoma npc as demonstrated previously in a small pilot study. Locally advanced nasopharyngeal carcinoma lanpc is a relatively rare disease in the west but more common in east asia and areas of the middle east like saudi arabia. The majority of published studies in recurrent or metastatic nasopharyngeal carcinoma rmnpc are singlearm trials. It starts in the upper part of your throat, behind the nose. Nasopharyngeal carcinoma npc is known for its highmetastatic potential. Multiinstitutional prospective study of nedaplatin plus s1. Thats probably because the nasopharynx isnt easy to examine and symptoms of nasopharyngeal carcinoma mimic those of other, morecommon conditions.
Nasopharyngeal carcinoma npc is an epithelial cancer etiologically linked to epsteinbarr virus ebv. In nasopharyngeal carcinoma patients diagnosed as having metastatic disease ab initio, the prognosis is poor, possibly reflecting the intrinsically aggressive behavior of the tumor. Npc is sensitive to chemotherapy to a great extent and survival prolongation could be achieved for recurrent disease, and possibly metastatic disease. An 18ffdgpetct scan and biopsy showed metastatic abdominal lymph nodes of nasopharyngeal carcinoma in april 2015. Nasopharyngeal carcinoma with metastases to colon sciencedirect. Multicenter, phase ii study of cetuximab in combination with. Nasopharyngeal carcinoma is characterised by distinct geographical distribution and is particularly prevalent in east and southeast asia. Treatment of recurrent and metastatic nasopharyngeal. In the current study, the authors present a phase 12 study to evaluate the effi. Nasopharyngeal carcinoma npc most nasopharyngeal cancers are nasopharyngeal carcinoma npc. Serglycin is a theranostic target in nasopharyngeal carcinoma. Nasopharyngeal carcinoma npc, or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the posterolateral nasopharynx or pharyngeal recess fossa of rosenmuller, accounting for 50% of cases. Comparative genomic expression profiling of npc cell line clones with high and lowmetastatic potential revealed the serglycin gene srgn as one of the most upregulated genes in. Treatment for metastatic nasopharyngeal carcinoma 81 table 2 results for bitherapy in local recurrence andor metastasis with or without pretreatment.
Nasopharyngeal carcinoma is difficult to detect early. The medline database was searched for the period 1980 to end 2009, using the keywords nasopharyngeal carcinoma, metastatic, chemotherapy and targeted therapy. Although rare in western europe and north america, npc is a leading cancer in southern china and southeast asia with an incidence rate of 1021. Nasopharyngeal carcinoma is a cancer arising from the nasopharynx epithelium. Phase ii study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma.
From basic information about cancer and its causes to indepth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here. Dec 05, 2017 the majority of published studies in recurrent or metastatic nasopharyngeal carcinoma rmnpc are singlearm trials. A single arm monotherapy study of pazopanib in patients with who type iiiii nasopharyngeal carcinoma who had metastatic recurrent disease and failed at least one line. Pancreasonly metastasis from nasopharyngeal carcinoma. The aim of the study was to describe the cytologic features of metastatic nasopharyngeal carcinomas npc to lymph node, which would help in arriving at a definite diagnosis, particularly in cases of occult primary with predominant finding of. Treatment modalities and prognostic factors were analyzed. To retrospectively analyze the prognosis of patients with nasopharyngeal carcinoma npc initially presenting with liver metastasis, in order to identify independent prognostic factors to facilitate management of treatment.
We designed this retrospective study to explore the best treatment modality for patients with initially metastatic nasopharyngeal carcinoma npc. Adoptive tcell transfer and chemotherapy in the first. Author study n protocol or % cr % med pfs med os wang t. Nasopharyngeal carcinoma npc is one of the most common malignancies in the head and neck region, especially among those of chinese origin. Nasopharyngeal cancer is a rare type of head and neck cancer. The present study is an update of recent data regarding the management of metastatic nasopharyngeal carcinoma. Nasopharyngeal carcinoma npc is known for its high metastatic potential. A computed tomographic ct scan of the head and neck showed a large left nasopharyngeal mass which extended across the. Nasopharyngeal carcinoma metastasis to the mammary gland. Ethnic background and being exposed to the epsteinbarr virus can affect the risk of nasopharyngeal cancer.
Nasopharyngeal carcinoma npc is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. A propensity score matching study xuesong sun sailan liu yujing liang qiuyan chen xiaoyun li linquan tang haiqiang mai department of nasopharyngeal carcinoma, state key laboratory of oncology in south china, collaborative innovation center for cancer medicine. Although the role of grayscale sonography for neck nodes is well documented, it plays a limited role in the evaluation of nodal response to treatment. Detection of bone metastasis in nasopharyngeal carcinoma by bone scintigraphy. Prognostic factors in nasopharyngeal carcinoma with. A phase ii study of pazopanib in asian patients with. Prolonged survival in a nasopharyngeal carcinoma patient. Clinically relevant mouse models are necessary for further understanding and drug discovery in this disease. Nasopharyngeal carcinoma clinical trials mayo clinic. Nasopharyngeal carcinoma npc represents a rare disease in the western countries, such as europe and usa, while its frequency reaches 20 cases per 100,000 people in the eastern countries, such as china, japan, and singapore. Nasopharyngeal carcinoma executive summary globally, nasopharyngeal carcinoma npc is an uncommon cancer with approximately 80,000 new cases reported per year and accounting 0. The nasopharynx is the upper part of the pharynx throat behind the nose.
Nasopharyngeal carcinoma metastatic to the cauda equina pdf. Pdf nasopharyngeal carcinoma metastatic to the mandible. Unlike other malignancies of the head and neck region, in which surgery remains the primary mode of treatment, radiotherapy is the treatment of choice in patients with early. Multicenter, phase ii study of cetuximab in combination. Pdf cytologic features of metastatic nasopharyngeal.
In the coming era of cancer immunotherapy, prognostic factors for lanpc need to be further defined using immunerelevant markers. These findings probably reflect lifestyle and environmental changes, enhanced understanding of the. A biopsy of the left cervical lymph nodes showed a similar pathological finding of metastatic undifferentiated carcinoma. Nasopharyngeal carcinoma of the undifferentiated histologic subtype is endemic and prevalent in southeast asia. Npc differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. Rare metastasis of nasopharyngeal carcinoma to the thyroid. Pdf metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma npc. Capecitabine monotherapy for recurrent and metastatic. In the coming era of cancer immunotherapy, prognostic factors for lanpc need to be further defined using immunerelevant. Nasopharyngeal carcinoma npc is the most common head and neck cancer in southern china, especially in the guangdong province cao et al.
Radiation therapy for nasopharyngeal carcinoma is usually administered in a procedure called external. Most nasopharyngeal cancers are nasopharyngeal carcinoma npc. Nasopharyngeal carcinoma is highly prevalent in southern china and is often resistant to current treatment options. Tel2 suppresses metastasis by downregulating serpine1 in nasopharyngeal carcinoma.
Oct 24, 2017 the majority of published studies in recurrent or metastatic nasopharyngeal carcinoma rmnpc are singlearm trials. Nccn quick guide sheet for metastatic breast cancer. Aug 17, 2018 nasopharyngeal carcinoma is difficult to detect early. Epidemiological trends in the past decade have shown that its incidence has declined gradually but progressively, and mortality has been reduced substantially. Two nasopharyngeal carcinoma cell lines, stably expressing green fluorescent protein gfp, 58fgfp and 610bgfp, were.
Oct 12, 2018 according to globocan 2012, there were 86,691 new cases of nasopharyngeal carcinoma npc and 50,831 deaths worldwide. Nasopharyngeal carcinoma npc, of epidermal origin, constitutes 90% of malignant nasopharyngeal tumors. Within the boundaries of the nasopharynx, the tumour epicentre is frequently seen at the fossa of rosenmuller, from where the tumour invades adjacent anatomical spaces or organs. Request pdf treatment for metastatic nasopharyngeal carcinoma nasopharyngeal carcinoma npc is a specific entity different from head and neck carcinoma. Here we report the identification of the proteoglycan serglycin as a functionally significant regulator of metastasis in this setting. Nasopharyngeal carcinoma is endemic in asia and angiogenesis is important for growth and progression. Despite the advances in radiation therapy techniques, some patients relapse after treatment. Nasopharyngeal carcinoma symptoms and causes mayo clinic. Radiation therapy uses highpowered energy beams, such as xrays or protons, to kill cancer cells. Signs of nasopharyngeal cancer include trouble breathing, speaking, or hearing. Earlystage and intermediatestage nasopharyngeal cancer npc generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. Prolonged survival in a nasopharyngeal carcinoma patient with. Nccn guidelines for patients metastatic breast cancer nccn quick guide sheet for noninvasive breast cancer.
Treatment for nasopharyngeal carcinoma usually begins with radiation therapy or a combination of radiation and chemotherapy. Metastatic sites are usually multifocal and involve the bones, lungs and distant lymph nodes. Reliable modelling of progressionfree survival pfs and overall survival os outcomes, therefore, is difficult. The criteria for the diagnosis of metastatic retropharyngeal lymph nodes rlns have not yet been resolved and are not included in the current edition of the american joint committee on cancer ajcc staging system seventh edition for the staging of nasopharyngeal carcinoma npc. The world health organization who definition of nasopharyngeal carcinoma is a carcinoma arising in the nasopharyngeal mucosa that shows light microscopic or ultrastructural evidence of squamous differentiation. Whether you or someone you love has cancer, knowing what to expect can help you cope. The dramatic improvement of treatment outcomes and overall prognosis during the past few decades has been attributed to advances in disease screening and diagnosis, diagnostic imaging, radiotherapy techniques, use of combination systemic therapy, and dedicated. Npc has multifactorial aetiologies including genetic susceptibility, consumption of food with high salt. Nasopharyngeal carcinoma patients with retropharyngeal. Comparative genomic expression profiling of npc cell line clones with high and low metastatic potential revealed the serglycin gene srgn as one of the most upregulated genes in. Metastatic adenopathy from nasopharyngeal carcinoma. It is by far the most common cancer in the nasopharynx.
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